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TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads.

Low, Hui Zhi
; 
Ahrenstorf, Gerrit
; ; 
Habermann, Nadine
; ; 
Ordóñez, David
; 
Stripecke, Renata
; ; 
Witte, Torsten
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2016
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Abstract
LILRA3 is an immunostimulatory molecule which can conditionally induce the proliferation of cytotoxic cells. LILRA3 has a deletion genotype which is associated with multiple immune disorders. In this study, we wanted to analyze the regulation of LILRA3 and its significance in the context of HIV infection.
Citation
TLR8 regulation of LILRA3 in monocytes is abrogated in human immunodeficiency virus infection and correlates to CD4 counts and virus loads. 2016, 13 (1):15 Retrovirology
Affiliation
Department of Clinical Immunology and Rheumatology, Hannover Medical School, Carl-Neuberg-Str. 1, 30625, Hannover, Germany.
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Journal
Retrovirology
URI
http://hdl.handle.net/10033/606041
DOI
10.1186/s12977-016-0248-y
PubMed ID
26969150
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Article
Language
en
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ISSN
1742-4690
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publications of the research group infection genetics (INFG)