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Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer.

Radmanesh, Hoda
; 
Spethmann, Tessa
; 
Enßen, Julia
; 
Schürmann, Peter
; 
Bhuju, Sabin
; ; 
Antonenkova, Natalia
; 
Khusnutdinova, Elza
; 
Sadr-Nabavi, Ariane
; 
Shandiz, Fatemeh Homaei
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Issue Date
2017-02
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Abstract
APOBEC3B belongs to the family of DNA-editing enzymes. A copy number variant targeting the genomic APOBEC3A-APOBEC3B locus has a significant impact on breast cancer risk, but the relative contribution of APOBEC3B is uncertain. In this study, we investigate a loss-of-function mutation that selectively targets APOBEC3B, for its association with breast cancer risk.
Citation
Assessment of an APOBEC3B truncating mutation, c.783delG, in patients with breast cancer. 2017, 162 (1):31-37 Breast Cancer Res. Treat.
Affiliation
Helmholtz Centre for infection research, Inhoffenstr.7, 38124 Braunschweig, Germany.
Publisher
Journal
Breast cancer research and treatment
URI
http://hdl.handle.net/10033/620962
DOI
10.1007/s10549-016-4100-9
PubMed ID
28062980
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Article
Language
en
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ISSN
1573-7217
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publications of the research group genomeanalytics (GMAK)