Loading...
Polyketide-Derived Secondary Metabolites from a Dothideomycetes Fungus, . et . ., (Muyocopronales) with Antimicrobial and Cytotoxic Activities.
Mapook, Ausana Macabeo, Allan Patrick G Thongbai, Benjarong Hyde, Kevin D Stadler, Marc
Mapook, Ausana
Macabeo, Allan Patrick G
Thongbai, Benjarong
Hyde, Kevin D
Stadler, Marc
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2020-04-08
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 3.04 MB
Other Titles
Abstract
Pseudopalawania siamensisgen. et sp. nov., from northern Thailand, is introduced based on multi-gene analyses and morphological comparison. An isolate was fermented in yeast malt culture broth and explored for its secondary metabolite production. Chromatographic purification of the crude ethyl acetate (broth) extract yielded four tetrahydroxanthones comprised of a new heterodimeric bistetrahydroxanthone, pseudopalawanone (1), two known dimeric derivatives, 4,4'-secalonic acid D (2) and penicillixanthone A (3), the corresponding monomeric tetrahydroxanthone paecilin B (4), and the known benzophenone, cephalanone F (5). Compounds 1-3 showed potent inhibitory activity against Gram-positive bacteria. Compounds 2 and 3 were inhibitory against Bacillus subtilis with minimum inhibitory concentrations (MIC) of 1.0 and 4.2 μg/mL, respectively. Only compound 2 showed activity against Mycobacterium smegmatis. In addition, the dimeric compounds 1-3 also showed moderate cytotoxic effects on HeLa and mouse fibroblast cell lines, which makes them less attractive as candidates for development of selectively acting antibiotics.
Citation
Biomolecules. 2020 Apr 8;10(4). pii: biom10040569. doi: 10.3390/biom10040569.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
EISSN
2218-273X
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International