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Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes.
Möhle, Luisa Israel, Nicole Paarmann, Kristin Krohn, Markus Pietkiewicz, Sabine Müller, Andreas Lavrik, Inna N Buguliskis, Jeffrey S Schott, Björn H Schlüter, Dirk
Möhle, Luisa
Israel, Nicole
Paarmann, Kristin
Krohn, Markus
Pietkiewicz, Sabine
Müller, Andreas
Lavrik, Inna N
Buguliskis, Jeffrey S
Schott, Björn H
Schlüter, Dirk
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Abstract
Alzheimer's disease (AD) is associated with the accumulation of β-amyloid (Aβ) as senile plaques in the brain, thus leading to neurodegeneration and cognitive impairment. Plaque formation depends not merely on the amount of generated Aβ peptides, but more importantly on their effective removal. Chronic infections with neurotropic pathogens, most prominently the parasite Toxoplasma (T.) gondii, are frequent in the elderly, and it has been suggested that the resulting neuroinflammation may influence the course of AD. In the present study, we investigated how chronic T. gondii infection and resulting neuroinflammation affect plaque deposition and removal in a mouse model of AD.
Citation
Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. 2016, 4 (1):25 Acta Neuropathol Commun
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PubMed ID
PubMed Central ID
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Article
Language
en
Description
Series/Report no.
ISSN
2051-5960