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Effect modification of the association between comorbidities and severe course of COVID-19 disease by age of study participants: a systematic review and meta-analysis.
Fernández Villalobos, Nathalie Verónica Ott, Jördis Jennifer Klett-Tammen, Carolina Judith Bockey, Annabelle Vanella, Patrizio Krause, Gérard Lange, Berit
Fernández Villalobos, Nathalie Verónica
Ott, Jördis Jennifer
Klett-Tammen, Carolina Judith
Bockey, Annabelle
Vanella, Patrizio
Krause, Gérard
Lange, Berit
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2021-06-30
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Abstract
Adjusting the protecting group strategy, from an alkyl ether to a bidentate ketal at the carbohydrate backbone of uridine, facilitates a switchable diastereoselective α- or β-C4'/C5'-spirocyclopropanation. Using these spirocyclopropanated nucleosides as key intermediates, we synthesized a variety of C4'-methylated d-ribose and l-lyxose-configured uridine derivatives by a base-mediated ring-opening of the spirocyclopropanol moiety. Investigations of antiviral activity against the human respiratory syncytial virus were carried out for selected derivatives, showing moderate activity.
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Syst Rev. 2021 Jun 30;10(1):194. doi: 10.1186/s13643-021-01732-3.
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en
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2046-4053