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7-O-malonyl macrolactin A, a new macrolactin antibiotic from Bacillus subtilis active against methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia.
Romero-Tabarez, Magally Jansen, Rolf Sylla, Marita Lünsdorf, Heinrich Häussler, Susanne Santosa, Dwi A Timmis, Kenneth N Molinari, Gabriella
Romero-Tabarez, Magally
Jansen, Rolf
Sylla, Marita
Lünsdorf, Heinrich
Häussler, Susanne
Santosa, Dwi A
Timmis, Kenneth N
Molinari, Gabriella
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2006-05-01
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Abstract
We report here the discovery, isolation, and chemical and preliminary biological characterization of a new antibiotic compound, 7-O-malonyl macrolactin A (MMA), produced by a Bacillus subtilis soil isolate. MMA is a bacteriostatic antibiotic that inhibits a number of multidrug-resistant gram-positive bacterial pathogens, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant enterococci, and a small-colony variant of Burkholderia cepacia. MMA-treated staphylococci and enterococci were pseudomulticellular and exhibited multiple asymmetric initiation points of septum formation, indicating that MMA may inhibit a cell division function.
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Antimicrob. Agents Chemother. 2006, 50(5):1701-9
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Article
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en
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0066-4804