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Langat virus infection affects hippocampal neuron morphology and function in mice without disease signs.
Cornelius, Angela D A Hosseini, Shirin Schreier, Sarah Fritzsch, David Weichert, Loreen Michaelsen-Preusse, Kristin Fendt, Markus Kröger, Andrea
Cornelius, Angela D A
Hosseini, Shirin
Schreier, Sarah
Fritzsch, David
Weichert, Loreen
Michaelsen-Preusse, Kristin
Fendt, Markus
Kröger, Andrea
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2020-09-20
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Abstract
To compare the effect of low and high viral replication in the brain, wildtype and Irf-7-/- mice were infected with Langat virus (LGTV), which belongs to the TBEV-serogroup. The viral burden was analyzed in the olfactory bulb and the hippocampus. Open field, elevated plus maze, and Morris water maze experiments were performed to determine the impact on anxiety-like behavior, learning, and memory formation. Spine density of hippocampal neurons and activation of microglia and astrocytes were analyzed.
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Neuroinflammation. 2020 Sep 20;17(1):278. doi: 10.1186/s12974-020-01951-w.
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en
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1742-2094
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Attribution-NonCommercial-ShareAlike 4.0 International