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Correlation of Severity of Human Tick-Borne Encephalitis Virus Disease and Pathogenicity in Mice.

Kurhade, Chaitanya
; 
Schreier, Sarah
; 
Lee, Yi-Ping
; 
Zegenhagen, Loreen
; 
Hjertqvist, Marika
; 
Dobler, Gerhard
; ; 
Överby, Anna K
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2018-09-01
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Abstract
We compared 2 tick-borne encephalitis virus strains isolated from 2 different foci that cause different symptoms in tick-borne encephalitis patients, from neurologic to mild gastrointestinal symptoms. We compared neuroinvasiveness, neurovirulence, and proinflammatory cytokine response in mice and found unique differences that contribute to our understanding of pathogenesis
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Affiliation
HZI,Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7,38124 Braunschweig, Germany.
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URI
http://hdl.handle.net/10033/621578
DOI
10.3201/eid2409.171825
PubMed ID
30124404
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ISSN
1080-6059
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Attribution-NonCommercial-ShareAlike 3.0 United States
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publications of the research group immunity and infection (IMMI)