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A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus.
Tsuda, Yoshimi Caposio, Patrizia Parkins, Christopher J Botto, Sara Messaoudi, Ilhem Cicin-Sain, Luka Feldmann, Heinz Jarvis, Michael A
Tsuda, Yoshimi
Caposio, Patrizia
Parkins, Christopher J
Botto, Sara
Messaoudi, Ilhem
Cicin-Sain, Luka
Feldmann, Heinz
Jarvis, Michael A
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2011-08
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Abstract
Human outbreaks of Ebola virus (EBOV) are a serious human health concern in Central Africa. Great apes (gorillas/chimpanzees) are an important source of EBOV transmission to humans due to increased hunting of wildlife including the 'bush-meat' trade. Cytomegalovirus (CMV) is an highly immunogenic virus that has shown recent utility as a vaccine platform. CMV-based vaccines also have the unique potential to re-infect and disseminate through target populations regardless of prior CMV immunity, which may be ideal for achieving high vaccine coverage in inaccessible populations such as great apes.
Citation
A replicating cytomegalovirus-based vaccine encoding a single Ebola virus nucleoprotein CTL epitope confers protection against Ebola virus. 2011, 5 (8):e1275 PLoS Negl Trop Dis
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Article
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en
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1935-2735