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A dual role for hepatocyte-intrinsic canonical NF-κB signaling in virus control.
Namineni, Sukumar O'Connor, Tracy Faure-Dupuy, Suzanne Johansen, Pål Riedl, Tobias Liu, Kaijing Xu, Haifeng Singh, Indrabahadur Shinde, Prashant Li, Fanghui
Namineni, Sukumar
O'Connor, Tracy
Faure-Dupuy, Suzanne
Johansen, Pål
Riedl, Tobias
Liu, Kaijing
Xu, Haifeng
Singh, Indrabahadur
Shinde, Prashant
Li, Fanghui
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2020-01-15
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Using lymphocytic choriomeningitis virus (LCMV) as a model of liver infection, we first assessed the role of myeloid cells by depletion prior to infection. We investigated the role of hepatocyte-intrinsic innate immune signaling by infecting mice lacking canonical NF-κB signaling (IKKβΔHep) specifically in hepatocytes. In addition, mice lacking hepatocyte-specific interferon-α/β signaling-(IFNARΔHep), or interferon-α/β signaling in myeloid cells-(IFNARΔMyel) were infected.
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J Hepatol. 2020 Jan 15. pii: S0168-8278(20)30010-6. doi: 10.1016/j.jhep.2019.12.019.
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1600-0641
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Attribution-NonCommercial-ShareAlike 4.0 International