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GLUCOSE SENSOR: COMPARISON OF ENZYMATIC AND ELECTROCATALYTIC PRINCIPLES
Lucadou, I. v. Preidel, W. Rao, J. R.
Lucadou, I. v.
Preidel, W.
Rao, J. R.
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Issue Date
1987
Submitted date
2023-08-30
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Abstract
An enzymatic glucose sensor using glucose oxidase (1) and especially an electrocatalytic sensor oxidizing glucose directly (2) are under investigation for the intracorporal measurement of glucose. Both are based on electrochemical principle. Though we have mainly pursued the latter one, both systems will be compared by presenting some experimental results. The enzymatic sensor was designed in a simple way: Pt-electrode/glucose oxidase solution/membrane. This sensor is featured by the residual current due to direct oxidation of glucose at the electrode, the effect of H20.2 which results as a product of enzymatic oxidation of glucose and the presence or absence of oxygen during the glucose measurement. In the electrocatalytic sensor, the membrane covered Pt-electrode is subjected to a potential-jump in cycle between a working and a rejuvenating potential. Either the charge derived at the working potential or the impedance obtained at two different frequencies for various potential steps is a measure for the glucose concentration. Its performance is mainly determined by the electrode poisoning and the membrane properties. However, these conditions can be optimized and, as will be shown, glucose still be measured in saline solutions, serum and blood. The electrocatalytic sensor is promising because of its long term stability though its selectivity poses a problem. It is just the opposite in enzyme sensor since the enzyme is not stable over longer periods.
Citation
Biosensors International Workshop 1987, 269 - 270
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Book chapter
conference paper
conference paper
Language
en
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Series/Report no.
GBF Monographs, Volume 10
ISSN
0930-4320
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ISBN
0-89573-683-7
3-527-26801-4
3-527-26801-4
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Attribution-NonCommercial-ShareAlike 4.0 International