Loading...
INCORPORATION OF FUCOSE INTO CHICK BRAIN GLYCOPROTEINS: EFFECTS OF THE AMNESIC AGENT 2-DEOXYGALACTOSE
Bullock, S. Potter, J. Rose, S. P. R.
Bullock, S.
Potter, J.
Rose, S. P. R.
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
1991
Submitted date
2024-02-20
Files
Loading...
PDF
Adobe PDF, 2.06 MB
Other Titles
Abstract
The amnesic agent 2-deoxygalactose inhibited total exogenous [}4c}fucose incorporation into chick forebrain glycoproteins by 26%. Sodium dodecyl sulphate-polyacrylamide gel electrophoretic analysis showedthat intracerebrally injected [3H]2-deoxygalactose labelled the same eight major glycoprotein components as were identified by [4Cjfucose labelling. Between 4 and 24 hours after administration of [3H]2-deoxygalactose, the incorporated radioactivity was found predominantly at the synapticsites, some glycoproteins being more abundant in synaptic plasma membranesandothers in postsynaptic densities. The pattern of distribution varied according to the timeafter injection. One-trial passive avoidance training of chicks decreased fucose uptake into components of molecular mass 150-180 kilodaltons butsignificantly increased its uptake into glycoproteins of molecular mass 33 kilodaltons and 28 kilodaltons.
Citation
Protein glycosylation, 53 - 56
DOI
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 15
ISSN
0930-4320
EISSN
ISBN
1560811846
3527283676
3527283676
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International