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Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice.
Prajeeth, Chittappen K Beineke, Andreas Iskandar, Cut Dahlia Gudi, Viktoria Herder, Vanessa Gerhauser, Ingo Haist, Verena Teich, René Huehn, Jochen Baumgärtner, Wolfgang
Prajeeth, Chittappen K
Beineke, Andreas
Iskandar, Cut Dahlia
Gudi, Viktoria
Herder, Vanessa
Gerhauser, Ingo
Haist, Verena
Teich, René
Huehn, Jochen
Baumgärtner, Wolfgang
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Abstract
Theiler's murine encephalomyelitis virus (TMEV) infection represents a commonly used infectious animal model to study various aspects of the pathogenesis of multiple sclerosis (MS). In susceptible SJL mice, dominant activity of Foxp3(+) CD4(+) regulatory T cells (Tregs) in the CNS partly contributes to viral persistence and progressive demyelination. On the other hand, resistant C57BL/6 mice rapidly clear the virus by mounting a strong antiviral immune response. However, very little is known about the role of Tregs in regulating antiviral responses during acute encephalitis in resistant mouse strains.
Citation
Limited role of regulatory T cells during acute Theiler virus-induced encephalitis in resistant C57BL/6 mice. 2014, 11:180 J Neuroinflammation
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PubMed ID
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Article
Language
en
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Series/Report no.
ISSN
1742-2094