Loading...
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory.
Pace, Luigia Tempez, Andy Arnold-Schrauf, Catharina Lemaitre, Fabrice Bousso, Philippe Fetler, Luc Sparwasser, Tim Amigorena, Sebastian
Pace, Luigia
Tempez, Andy
Arnold-Schrauf, Catharina
Lemaitre, Fabrice
Bousso, Philippe
Fetler, Luc
Sparwasser, Tim
Amigorena, Sebastian
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2012-10-26
Submitted date
Files
Loading...
supplemental materials
Adobe PDF, 1.82 MB
Loading...
original manuscript
Adobe PDF, 678.88 KB
Other Titles
Abstract
Although regulatory T cells (T(regs)) are known to suppress self-reactive autoimmune responses, their role during T cell responses to nonself antigens is not well understood. We show that T(regs) play a critical role during the priming of immune responses in mice. T(reg) depletion induced the activation and expansion of a population of low-avidity CD8(+) T cells because of overproduction of CCL-3/4/5 chemokines, which stabilized the interactions between antigen-presenting dendritic cells and low-avidity T cells. In the absence of T(regs), the avidity of the primary immune response was impaired, which resulted in reduced memory to Listeria monocytogenes. These results suggest that T(regs) are important regulators of the homeostasis of CD8(+) T cell priming and play a critical role in the induction of high-avidity primary responses and effective memory.
Citation
Regulatory T cells increase the avidity of primary CD8+ T cell responses and promote memory. 2012, 338 (6106):532-6 Science
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1095-9203
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Archived with thanks to Science (New York, N.Y.)