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Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against .
Sanchez Alberti, Andrés Bivona, Augusto E Matos, Marina N Cerny, Natacha Weißmann, Sebastian Ebensen, Thomas González, Germán Morales, Celina Cardoso, Alejandro C
Sanchez Alberti, Andrés
Bivona, Augusto E
Matos, Marina N
Cerny, Natacha
Weißmann, Sebastian
Ebensen, Thomas
González, Germán
Morales, Celina
Cardoso, Alejandro C
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2020-02-21
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Abstract
There are several unmet needs in modern immunology. Among them, vaccines against parasitic diseases and chronic infections lead. Trypanosoma cruzi, the causative agent of Chagas disease, is an excellent example of a silent parasitic invasion that affects millions of people worldwide due to its progression into the symptomatic chronic phase of infection. In search for novel vaccine candidates, we have previously introduced Traspain, an engineered trivalent immunogen that was designed to address some of the known mechanisms of T. cruzi immune evasion. Here, we analyzed its performance in different DNA prime/protein boost protocols and characterized the systemic immune response associated with diverse levels of protection. Formulations that include a STING agonist, like c-di-AMP in the boost doses, were able to prime a Th1/Th17 immune response. Moreover, comparison between them showed that vaccines that were able to prime polyfunctional cell-mediated immunity at the CD4 and CD8 compartment enhanced protection levels in the murine model. These findings contribute to a better knowledge of the desired vaccine-elicited immunity against T. cruzi and promote the definition of a vaccine correlate of protection against the infection.
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Front Immunol. 2020 Feb 21;11:128. doi: 10.3389/fimmu.2020.00128. eCollection 2020.
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en
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1664-3224
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Attribution-NonCommercial-ShareAlike 4.0 International