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The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility.

Menhofer, Magdalena H
; 
Kubisch, Rebekka
; 
Schreiner, Laura
; 
Zorn, Matthias
; 
Foerster, Florian
; 
Mueller, Rolf
; 
Raedler, Joachim O
; 
Wagner, Ernst
; 
Vollmar, Angelika M
; 
Zahler, Stefan
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2014
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Abstract
A major player in the process of metastasis is the actin cytoskeleton as it forms key structures in both invasion mechanisms, mesenchymal and amoeboid migration. We tested the actin binding compound Chondramide as potential anti-metastatic agent.
Citation
The actin targeting compound Chondramide inhibits breast cancer metastasis via reduction of cellular contractility. 2014, 9 (11):e112542 PLoS ONE
Affiliation
Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Saarbru ¨ cken, Germany.
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Journal
PloS one
URI
http://hdl.handle.net/10033/528570
DOI
10.1371/journal.pone.0112542
PubMed ID
25391145
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Article
Language
en
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1932-6203
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publications of the research group of microbial natural substances([HIPS]MINS)