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Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies.
Fofana, Isabel Fafi-Kremer, Samira Carolla, Patric Fauvelle, Catherine Zahid, Muhammad Nauman Turek, Marine Heydmann, Laura Cury, Karine Hayer, Juliette Combet, Christophe
Fofana, Isabel
Fafi-Kremer, Samira
Carolla, Patric
Fauvelle, Catherine
Zahid, Muhammad Nauman
Turek, Marine
Heydmann, Laura
Cury, Karine
Hayer, Juliette
Combet, Christophe
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2012-07
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Abstract
The development of vaccines and other strategies to prevent hepatitis C virus (HCV) infection is limited by rapid viral evasion. HCV entry is the first step of infection; this process involves several viral and host factors and is targeted by host-neutralizing responses. Although the roles of host factors in HCV entry have been well characterized, their involvement in evasion of immune responses is poorly understood. We used acute infection of liver graft as a model to investigate the molecular mechanisms of viral evasion.
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Mutations that alter use of hepatitis C virus cell entry factors mediate escape from neutralizing antibodies. 2012, 143 (1):223-233.e9 Gastroenterology
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en
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1528-0012
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