Thumbnail Image
Publication

Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton.

Sudhakar, Padhmanand
; 
Reck, Michael
; 
Wang, Wei
; 
He, Feng Q
; 
Dobler, Irene W
; 
Zeng, An-Ping
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2014
Submitted date
Show all metadata
Files
Thumbnail Image
OPen Access publication
Adobe PDF, 5.42 MB
Thumbnail Image
Erratum to publication
Adobe PDF, 169.33 KB
Other Titles
Abstract
Carolacton is a newly identified secondary metabolite causing altered cell morphology and death of Streptococcus mutans biofilm cells. To unravel key regulators mediating these effects, the transcriptional regulatory response network of S. mutans biofilms upon carolacton treatment was constructed and analyzed. A systems biological approach integrating time-resolved transcriptomic data, reverse engineering, transcription factor binding sites, and experimental validation was carried out.
Citation
Construction and verification of the transcriptional regulatory response network of Streptococcus mutans upon treatment with the biofilm inhibitor carolacton. 2014, 15:362 BMC Genomics
Affiliation
Publisher
Journal
BMC genomics
URI
http://hdl.handle.net/10033/322836
DOI
10.1186/1471-2164-15-362
PubMed ID
24884510
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1471-2164
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Archived with thanks to BMC genomics
Collections
publications of the research group microbial communication (KOM)