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Tcf1 cells are required to maintain the inflationary T cell pool upon MCMV infection.

Welten, Suzanne P M
; 
Yermanos, Alexander
; 
Baumann, Nicolas S
; 
Wagen, Franziska
; 
Oetiker, Nathalie
; 
Sandu, Ioana
; 
Pedrioli, Alessandro
; 
Oduro, Jennifer D
; 
Reddy, Sai T
; ... show 2 more
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Issue Date
2020-05-08
Submitted date
2019-10-28
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Abstract
Cytomegalovirus-based vaccine vectors offer interesting opportunities for T cell-based vaccination purposes as CMV infection induces large numbers of functional effector-like cells that accumulate in peripheral tissues, a process termed memory inflation. Maintenance of high numbers of peripheral CD8 T cells requires continuous replenishment of the inflationary T cell pool. Here, we show that the inflationary T cell population contains a small subset of cells expressing the transcription factor Tcf1. These Tcf1+ cells resemble central memory T cells and are proliferation competent. Upon sensing viral reactivation events, Tcf1+ cells feed into the pool of peripheral Tcf1- cells and depletion of Tcf1+ cells hampers memory inflation. TCR repertoires of Tcf1+ and Tcf1- populations largely overlap, with the Tcf1+ population showing higher clonal diversity. These data show that Tcf1+ cells are necessary for sustaining the inflationary T cell response, and upholding this subset is likely critical for the success of CMV-based vaccination approaches.
Citation
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Publisher
Springer Nature
Journal
Nature communications
URI
http://hdl.handle.net/10033/623232
DOI
10.1038/s41467-020-16219-3
PubMed ID
32385253
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Article
Language
en
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ISSN
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2041-1723
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Attribution 4.0 International
cb
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research group of viral immunology (VIRI)