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Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection.
Alberts, Rudi Srivastava, Barkha Wu, Haiya Viegas, Nuno Geffers, Robert Klawonn, Frank Novoselova, Natalia do Valle, Tania Zaverucha Panthier, Jean-Jacques Schughart, Klaus
Alberts, Rudi
Srivastava, Barkha
Wu, Haiya
Viegas, Nuno
Geffers, Robert
Klawonn, Frank
Novoselova, Natalia
do Valle, Tania Zaverucha
Panthier, Jean-Jacques
Schughart, Klaus
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2010-04
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Abstract
Inbred mouse strains exhibit differences in susceptibility to influenza A infections. However, the molecular mechanisms underlying these differences are unknown. Therefore, we infected a highly susceptible mouse strain (DBA/2J) and a resistant strain (C57BL/6J) with influenza A H1N1 (PR8) and performed genome-wide expression analysis. We found genes expressed in lung epithelium that were specifically down-regulated in DBA/2J mice, whereas a cluster of genes on chromosome 3 was only down-regulated in C57BL/6J. In both mouse strains, chemokines, cytokines and interferon-response genes were up-regulated, indicating that the main innate immune defense pathways were activated. However, many immune response genes were up-regulated in DBA/2J much stronger than in C57BL/6J, and several immune response genes were exclusively regulated in DBA/2J. Thus, susceptible DBA/2J mice showed a hyper-inflammatory response. This response is similar to infections with highly pathogenic influenza virus and may serve as a paradigm for a hyper-inflammatory host response to influenza A virus.
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Gene expression changes in the host response between resistant and susceptible inbred mouse strains after influenza A infection. 2010, 12 (4):309-18 Microbes Infect.
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en
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1769-714X