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Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity.

Westendorf, Astrid M
; 
Skibbe, Kathrin
; 
Adamczyk, Alexandra
; 
Buer, Jan
; ; 
Hansen, Wiebke
; 
Pastille, Eva
; 
Jendrossek, Verena
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Issue Date
2017
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Abstract
Hypoxia occurs in many pathological conditions, including inflammation and cancer. Within this context, hypoxia was shown to inhibit but also to promote T cell responses. Due to this controversial function, we aimed to explore whether an insufficient anti-tumour response during colitis-associated colon cancer could be ascribed to a hypoxic microenvironment.
Citation
Hypoxia Enhances Immunosuppression by Inhibiting CD4+ Effector T Cell Function and Promoting Treg Activity. 2017, 41 (4):1271-1284 Cell. Physiol. Biochem.
Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, 38124 Braunschweig, Germany.
Publisher
Journal
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
URI
http://hdl.handle.net/10033/621001
DOI
10.1159/000464429
PubMed ID
28278498
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Article
Language
en
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1421-9778
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publications of the research group genomeanalytics (GMAK)