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Antiviral Meroterpenoid Rhodatin and Sesquiterpenoids Rhodocoranes A-E from the Wrinkled Peach Mushroom, Rhodotus palmatus.
Sandargo, Birthe Michehl, Maira Praditya, Dimas Surup, Frank
Sandargo, Birthe
Michehl, Maira
Praditya, Dimas
Surup, Frank
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2019-05-03
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Rhodatin (1), a meroterpenoid featuring a unique pentacyclic scaffold with both spiro and spiroketal centers, and five unusual acorane-type sesquiterpenoids, named rhodocoranes A-E (2-6, respectively), are the first natural products isolated from the basidiomycete Rhodotus palmatus. Their structures were elucidated by two-dimensional NMR experiments and HRESIMS, while the absolute configuration of the substance family was determined by Mosher's method utilizing 2. Rhodatin strongly inhibited hepatitis C virus, whereas 4 displayed cytotoxicity and selective antifungal activity.
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Org Lett. 2019 May 3;21(9):3286-3289. doi: 10.1021/acs.orglett.9b01017. Epub 2019 Apr 22.
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en
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1523-7052
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Attribution-NonCommercial-ShareAlike 4.0 International