Loading...
An RNA-centric view on gut Bacteroidetes.
Ryan, Daniel Prezza, Gianluca Westermann, Alexander J
Ryan, Daniel
Prezza, Gianluca
Westermann, Alexander J
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2020-09-24
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 3.36 MB
Other Titles
Abstract
Bacteria employ noncoding RNAs to maintain cellular physiology, adapt global gene expression to fluctuating environments, sense nutrients, coordinate their interaction with companion microbes and host cells, and protect themselves against bacteriophages. While bacterial RNA research has made fundamental contributions to biomedicine and biotechnology, the bulk of our knowledge of RNA biology stems from the study of a handful of aerobic model species. In comparison, RNA research is lagging in many medically relevant obligate anaerobic species, in particular the numerous commensal bacteria comprising our gut microbiota. This review presents a guide to RNA-based regulatory mechanisms in the phylum Bacteroidetes, focusing on the most abundant bacterial genus in the human gut, Bacteroides spp. This includes recent case reports on riboswitches, an mRNA leader, cis- and trans-encoded small RNAs (sRNAs) in Bacteroides spp., and a survey of CRISPR-Cas systems across Bacteroidetes. Recent work from our laboratory now suggests the existence of hundreds of noncoding RNA candidates in Bacteroides thetaiotaomicron, the emerging model organism for functional microbiota research. Based on these collective observations, we predict mechanistic and functional commonalities and differences between Bacteroides sRNAs and those of other model bacteria, and outline open questions and tools needed to boost Bacteroidetes RNA research.
Citation
Biol Chem. 2020 Sep 24:/j/bchm.ahead-of-print/hsz-2020-0230/hsz-2020-0230.xml. doi: 10.1515/hsz-2020-0230. Epub ahead of print.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Other
Other
Language
en
Description
Series/Report no.
ISSN
EISSN
1437-4315
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 4.0 International