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Memantine potentiates cytarabine-induced cell death of acute leukemia correlating with inhibition of K1.3 potassium channels, AKT and ERK1/2 signaling.

Lowinus, Theresa
; 
Heidel, Florian H
; 
Bose, Tanima
; 
Nimmagadda, Subbaiah Chary
; 
Schnöder, Tina
; 
Cammann, Clemens
; ; 
Seifert, Ulrike
; 
Fischer, Thomas
; 
Schraven, Burkhart
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2019-01-16
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Abstract
Treatment of acute leukemia is challenging and long-lasting remissions are difficult to induce. Innovative therapy approaches aim to complement standard chemotherapy to improve drug efficacy and decrease toxicity. Promising new therapeutic targets in cancer therapy include voltage-gated K We analyzed acute lymphoid (Jurkat, CEM) and myeloid (HL-60, Molm-13, OCI-AML-3) leukemia cell lines and patients' acute leukemic blasts after treatment with either drug alone or the combination of cytarabine and memantine. Patch-clamp analysis was performed to evaluate inhibition of K Our study demonstrates that memantine inhibits K Our study underlines inhibition of K
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BMC
Journal
Cell Communication and Signaling
URI
http://hdl.handle.net/10033/621690
DOI
10.1186/s12964-018-0317-z
PubMed ID
30651113
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Article
Language
en
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1478-811X
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Attribution-NonCommercial-ShareAlike 4.0 International
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publications of the research group of immune control (IMMK)
publications of the AG system-oriented immunology and infection research (SIME)