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Saccharide-Containing Dynamic Proteoids.

Liu, Yun
; 
Stuart, Marc C A
; 
Witte, Martin D
; 
Buhler, Eric
; 
Hirsch, Anna K H
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2017-10-05
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Abstract
Dynamic proteoids are dynamic covalent analogues of proteins, which can be used as new adaptive biomaterials. We designed and synthesized a range of sugar-containing dynamic proteoid biodynamers based on the polycondensation of different types of amino acid and dipeptide hydrazides with a biological aliphatic dialdehyde and a nonbiological aromatic dialdehyde. By using the saccharide-based dialdehyde, the biocompatibility of biodynamers should be enhanced compared to previously reported biodynamers.
Citation
Saccharide-Containing Dynamic Proteoids. 2017 Chemistry
Affiliation
Helmholtz-Institute for Pharmaceutical Research Saarland (HIPS), Universitycampus E8.1, 66123 Saarbrücken, Germany.
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Journal
Chemistry (Weinheim an der Bergstrasse, Germany)
URI
http://hdl.handle.net/10033/621147
DOI
10.1002/chem.201703584
PubMed ID
28981987
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Article
Language
en
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1521-3765
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publications of the research group drug design and optimization(HIPS]DDOP)