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Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence.

Effenberger-Neidnicht, Katharina
; 
Breyer, Sandra
; 
Mahal, Katharina
; 
Sasse, Florenz
; 
Schobert, Rainer
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Issue Date
2012-01
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Abstract
Doxorubicin (1) is commonly used in the treatment of a wide range of cancers. Some N-acylhydrazones of 1 were previously found to have an improved tumour and organ selectivity. In order to clarify the molecular basis for this effect, the cellular uptake into various cancer cells and the localisation in PtK(2) potoroo kidney cells of 1 and its N-acylhydrazones derived from heptadecanoic acid (2) and 11-(menthoxycarbonyl)undecanoic acid (3) were studied drawing on their intrinsic fluorescence.
Citation
Modification of uptake and subcellular distribution of doxorubicin by N-acylhydrazone residues as visualised by intrinsic fluorescence. 2012, 69 (1):85-90 Cancer Chemother. Pharmacol.
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Journal
Cancer chemotherapy and pharmacology
URI
http://hdl.handle.net/10033/620839
DOI
10.1007/s00280-011-1675-z
PubMed ID
21607555
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Article
Language
en
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ISSN
1432-0843
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Publications of the research group Chemical Biology (CBIO)