Loading...
Analysis and Design of Stimulus Response Curves of E. coli.
Kremling, Andreas Goehler, Anna Jahreis, Knut Nees, Markus Auerbach, Benedikt Schmidt-Heck, Wolfgang Kökpinar, Oznur Geffers, Robert Rinas, Ursula Bettenbrock, Katja
Kremling, Andreas
Goehler, Anna
Jahreis, Knut
Nees, Markus
Auerbach, Benedikt
Schmidt-Heck, Wolfgang
Kökpinar, Oznur
Geffers, Robert
Rinas, Ursula
Bettenbrock, Katja
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2012-11-12
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 384.26 KB
Other Titles
Abstract
Metabolism and signalling are tightly coupled in bacteria. Combining several theoretical approaches, a core model is presented that describes transcriptional and allosteric control of glycolysis in Escherichia coli. Experimental data based on microarrays, signalling components and extracellular metabolites are used to estimate kinetic parameters. A newly designed strain was used that adjusts the incoming glucose flux into the system and allows a kinetic analysis. Based on the results, prediction for intracelluar metabolite concentrations over a broad range of the growth rate could be performed and compared with data from literature.
Citation
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
Description
Series/Report no.
ISSN
2218-1989
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-ShareAlike 3.0 United States