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Vaccines against typhoid fever.
Guzman, Carlos A Borsutzky, Stefan Griot-Wenk, Monika Metcalfe, Ian C Pearman, Jon Collioud, Andre Favre, Didier Dietrich, Guido
Guzman, Carlos A
Borsutzky, Stefan
Griot-Wenk, Monika
Metcalfe, Ian C
Pearman, Jon
Collioud, Andre
Favre, Didier
Dietrich, Guido
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Issue Date
2006-05-01
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Abstract
Because of high infectivity and significant disease burden, typhoid fever constitutes a major global health problem. Implementation of adequate food handling practices and establishment of safe water supplies are the cornerstone for the development of an effective prevention program. However, vaccination against typhoid fever remains an essential tool for the effective management of this disease. Currently, there are two well tolerated and effective licensed vaccines. One is based on defined subunit virulence (Vi) polysaccharide antigen and can be administered either intramuscularly or subcutaneously and the other is based on the use of live attenuated bacteria for oral administration. The advantages and disadvantages of the various approaches taken in the development of a vaccine against typhoid fever are discussed, along with the potential for future vaccine candidates.
Citation
Vaccines against typhoid fever. 2006, 24 (18):3804-11 Vaccine
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Article
Language
en
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Series/Report no.
ISSN
0264-410X