Loading...
Elimination of Staphylococcus aureus from the bloodstream using a novel biomimetic sorbent haemoperfusion device.
Seffer, Malin-Theres Eden, Gabriele Kielstein, Jan T
Seffer, Malin-Theres
Eden, Gabriele
Kielstein, Jan T
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2020-08-24
Submitted date
2022-05-06
Files
Other Titles
Abstract
Removal of bacteria from the blood by means of extracorporeal techniques has been attempted for decades. In late 2019, the European Union licensed the first ever haemoperfusion device for removal of bacteria from the blood. The active ingredient of Seraph 100 Microbind Affinity Blood Filter is ultrahigh molecular weight polyethylene beads with endpoint-attached heparin. Bacteria have been shown to bind to heparin as they would usually do to the heparan sulfate on the cell surface, thereby being removed from the blood stream. We describe the first case of a female chronic haemodialysis patient in which this device was clinically used for a Staphylococcus aureus infection that persisted for 4 days despite antibiotic therapy. After a single treatment, the bacterial load decreased and the blood cultures at the end of a 4 hour haemoperfusion exhibited no bacterial growth.
Citation
Affiliation
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Other
Other
Language
en
Description
Series/Report no.
ISSN
EISSN
1757-790X
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution 4.0 International