Loading...
Bacterial extracellular vesicles: Understanding biology promotes applications as nanopharmaceuticals.
Jahromi, Leila Pourtalebi Fuhrmann, Gregor
Jahromi, Leila Pourtalebi
Fuhrmann, Gregor
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2021-03-25
Submitted date
Files
Loading...
accepted manuscript
Adobe PDF, 2.6 MB
Other Titles
Abstract
Extracellular vesicle (EV)-mediated communication between proximal and distant cells is a highly conserved characteristic in all of the life domains, including bacteria. These vesicles that contain a variety of biomolecules, such as proteins, lipids, nucleic acids, and small-molecule metabolites play a key role in the biology of bacteria. They are one of the key underlying mechanisms behind harmful or beneficial effects of many pathogenic, symbiont, and probiotic bacteria. These nanoscale EVs mediate extensive crosstalk with mammalian cells and deliver their cargos to the host. They are stable in physiological condition, can encapsulate diverse biomolecules and nanoparticles, and their surface could be engineered with available technologies. Based on favorable characteristics of bacterial vesicles, they can be harnessed for designing a diverse range of therapeutics and diagnostics for treatment of disorders including tumors and resistant infections. However, technical limitations for their production, purification, and characterization must be addressed in future studies.
Citation
Adv Drug Deliv Rev. 2021 Mar 25;173:125-140. doi: 10.1016/j.addr.2021.03.012. Epub ahead of print.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Review
Language
en
Description
Series/Report no.
ISSN
EISSN
1872-8294
ISBN
ISMN
Gov't Doc #
Sponsors
License
Attribution-NonCommercial-NoDerivatives 4.0 International