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Developmental induction of human T-cell responses against Candida albicans and Aspergillus fumigatus.
Vogel, Katrin Pierau, Mandy Arra, Aditya Lampe, Karen Schlueter, Dirk Arens, Christoph Brunner-Weinzierl, Monika C
Vogel, Katrin
Pierau, Mandy
Arra, Aditya
Lampe, Karen
Schlueter, Dirk
Arens, Christoph
Brunner-Weinzierl, Monika C
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2018-11-15
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Abstract
The origin of human T-cell responses against fungal pathogens early in life is not clearly understood. Here, we show that antifungal T-cell responses are vigorously initiated within the first years of life against lysates and peptides of Candida albicans or Aspergillus fumigatus, presented by autologous monocytes. The neonatal responding T-cell pool consists of 20 different TCR-V
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2045-2322
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Attribution-NonCommercial-ShareAlike 4.0 International