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Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure.
Pfaender, Stephanie Walter, Stephanie Todt, Daniel Behrendt, Patrick Doerrbecker, Juliane Wölk, Benno Engelmann, Michael Gravemann, Ute Seltsam, Axel Steinmann, Joerg
Pfaender, Stephanie
Walter, Stephanie
Todt, Daniel
Behrendt, Patrick
Doerrbecker, Juliane
Wölk, Benno
Engelmann, Michael
Gravemann, Ute
Seltsam, Axel
Steinmann, Joerg
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2015-09
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Abstract
The recent discovery of hepatitis C virus (HCV)-related viruses in different animal species has raised new speculations regarding the origin of HCV and the possibility of a zoonotic source responsible for the endemic HCV transmission. As a consequence, these new findings prompt questions regarding the potential for cross-species transmissions of hepaciviruses. The closest relatives to HCV discovered to date are the non-primate hepaciviruses (NPHVs), which have been described to infect horses. To evaluate the risk of a potential zoonotic transmission, we analysed NPHV RNA and antibodies in humans with occupational exposure to horses in comparison with a low-risk group. Both groups were negative for NPHV RNA, even though low seroreactivities against various NPHV antigens could be detected irrespective of the group. In conclusion, we did not observe evidence of NPHV transmission between horses and humans.
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Assessment of cross-species transmission of hepatitis C virus-related non-primate hepacivirus in a population of humans at high risk of exposure. 2015, 96 (9):2636-42 J. Gen. Virol.
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en
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1465-2099
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openAccess