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Humanized mouse model supports development, function, and tissue residency of human natural killer cells.

Herndler-Brandstetter, Dietmar
; 
Shan, Liang
; 
Yao, Yi
; 
Stecher, Carmen
; 
Plajer, Valerie
; 
Lietzenmayer, Melanie
; ; 
de Zoete, Marcel R
; 
Palm, Noah W
; 
Chen, Jie
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Issue Date
2017-11-07
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Abstract
Immunodeficient mice reconstituted with a human immune system represent a promising tool for translational research as they may allow modeling and therapy of human diseases in vivo. However, insufficient development and function of human natural killer (NK) cells and T cell subsets limit the applicability of humanized mice for studying cancer biology and therapy. Here, we describe a human interleukin 15 (
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Affiliation
Helmholtz-Zentrum für Infektionsforschung GmbH, Inhoffenstr. 7, 38124 Braunschweig, Germany.
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URI
http://hdl.handle.net/10033/621468
DOI
10.1073/pnas.1705301114
PubMed ID
29078283
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Article
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ISSN
1091-6490
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Attribution-NonCommercial-ShareAlike 3.0 United States
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publications of the research group microbial immunoregulation (MIKI)