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Amycolatomycins A and B, Cyclic Hexapeptides Isolated from an amycolatopsis sp. 195334CR.
Primahana, Gian Risdian, Chandra Mozef, Tjandrawati Wink, Joachim
Primahana, Gian
Risdian, Chandra
Mozef, Tjandrawati
Wink, Joachim
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2021-03-05
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Abstract
The rare actinobacterium Amycolatopsis sp. strain 195334CR was found to produce previously undescribed cyclic hexapeptides, which we named amycolatomycin A and B (1 and 2). Their planar structures were determined by high-resolution mass spectrometry as well as extensive 1D and 2D NMR spectroscopy, while the absolute stereochemistry of its amino acids were determined by Marfey's method. Moreover, 1 and 2 differ by the incorporation of l-Ile and l-allo-Ile, respectively, whose FDVA (Nα-(2,4-Dinitro-5-fluorphenyl)-L-valinamide) derivatives were separated on a C4 column. Their hallmark in common is a unique 2,6-dichloro-tryptophan amino acid unit. Amycolatomycin A (1) exhibited weak activity against Bacillus subtilis DSM 10 (minimum inhibitory concentration (MIC) = 33.4 µg/mL).
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Antibiotics (Basel). 2021 Mar 5;10(3):261. doi: 10.3390/antibiotics10030261.
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en
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2079-6382
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Attribution 4.0 International