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Investigations to the Antibacterial Mechanism of Action of Kendomycin.

A Elnakady, Yasser
; 
Chatterjee, Indranil
; 
Bischoff, Markus
; 
Rohde, Manfred
; 
Josten, Michaele
; 
Sahl, Hans-Georg
; 
Herrmann, Mathias
; 
Müller, Rolf
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2016
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Abstract
The emergence of bacteria that are resistant to many currently used drugs emphasizes the need to discover and develop new antibiotics that are effective against such multi-resistant strains. Kendomycin is a novel polyketide that has a unique quinone methide ansa structure and various biological properties. This compound exhibits strong antibacterial activity against Gram-negative and Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). Despite the promise of kendomycinin in several therapeutic areas, its mode of action has yet to be identified.
Citation
Investigations to the Antibacterial Mechanism of Action of Kendomycin. 2016, 11 (1):e0146165 PLoS ONE
Affiliation
Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research and Department of Pharmaceutical Biotechnology, Saarland University, Saarbrücken, Germany.
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PloS one
URI
http://hdl.handle.net/10033/601041
DOI
10.1371/journal.pone.0146165
PubMed ID
26795276
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Article
Language
en
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1932-6203
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publications of the research group of microbial natural substances([HIPS]MINS)