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TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells.
Warnecke, Nicole Poltorak, Mateusz Kowtharapu, Bhavani S Arndt, Boerge Stone, James C Schraven, Burkhart Simeoni, Luca
Warnecke, Nicole
Poltorak, Mateusz
Kowtharapu, Bhavani S
Arndt, Boerge
Stone, James C
Schraven, Burkhart
Simeoni, Luca
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2012-04
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Abstract
Sos proteins are ubiquitously expressed activators of Ras. Lymphoid cells also express RasGRP1, another Ras activator. Sos and RasGRP1 are thought to cooperatively control full Ras activation upon T-cell receptor triggering. Using RNA interference, we evaluated whether this mechanism operates in primary human T cells. We found that T-cell antigen receptor (TCR)-mediated Erk activation requires RasGRP1, but not Grb2/Sos. Conversely, Grb2/Sos—but not RasGRP1—are required for IL2-mediated Erk activation. Thus, RasGRP1 and Grb2/Sos are insulators of signals that lead to Ras activation induced by different stimuli, rather than cooperating downstream of the TCR.
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TCR-mediated Erk activation does not depend on Sos and Grb2 in peripheral human T cells. 2012, 13 (4):386-91 EMBO Rep.
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en
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1469-3178
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Archived with thanks to EMBO reports