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Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help.
Grenningloh, R Darj, A Bauer, H zur Lage, S Chakraborty, T Jacobs, T Weiss, S
Grenningloh, R
Darj, A
Bauer, H
zur Lage, S
Chakraborty, T
Jacobs, T
Weiss, S
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2008-06
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Abstract
Protection against intracellular pathogens is usually mediated by cytotoxic T lymphocytes (CTL). Induction of a protective CTL response for vaccination purposes has proven difficult because of the limited access of protein antigens or attenuated pathogens to the MHC class I presentation pathway. We show here that pH-sensitive PE/CHEMS liposomes can be used as a vehicle to efficiently deliver intact proteins for presentation by MHC class I. Mice immunized with listerial proteins encapsulated in such liposomes launched a strong CTL response and were protected against a subsequent challenge with L. monocytogenes. Remarkably, the CTL response was induced independently of detectable CD4(+) T cell help.
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Liposome-encapsulated antigens induce a protective CTL response against Listeria monocytogenes independent of CD4+ T cell help. 2008, 67 (6):594-602 Scand. J. Immunol.
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Article
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en
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1365-3083