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ENZYME ELECTRODES FOR MEDICAL APPLICATIONS
Pfeiffer, Dorothea Setz, K. Klimes, Norbert Makower, A. Schulmeister, Thomas Scheller, Frieder W.
Pfeiffer, Dorothea
Setz, K.
Klimes, Norbert
Makower, A.
Schulmeister, Thomas
Scheller, Frieder W.
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Issue Date
1992
Submitted date
2024-04-10
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Adobe PDF, 3.35 MB
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Abstract
1.The development and optimization of a highly sensitive creatine sensor based on the creatine amidinohydrolase - sarcosine oxidase sequence is described. The bi-enzyme sensor for the analysis of creatinine and creatine kinase is characterized by the following analytical performance: response time below 15 s, detection limit 5 uM creatine, linear concentration range up to 500 uM creatine, functional stability more than & days, serial imprecision below 5 %, measuring range for CK between 1 and 1000 U/l. 2. A well designed modified lactate sensor based on a cellulose-lactate oxidase/polycarbonate-cellulose membrane system is demonstrated for the accurate analysis of lactate in a concentration range between 0.2 and 20 mM using undiluted whole blood. This sensor now is commercialized as the main part of the BIOSENLactat2000 (EKF Industrie-Elektronik Magdeburg, Germany).
Citation
Biosensors : fundamentals, technologies and applications, 11 - 18
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Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 17
ISSN
0930-4320
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ISBN
3527284370
1560812206
1560812206
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Attribution-NonCommercial-ShareAlike 4.0 International