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Protein homeostasis-more than resisting a hot bath.
Lee, Changhan Wigren, Edvard Lünsdorf, Heinrich Römling, Ute
Lee, Changhan
Wigren, Edvard
Lünsdorf, Heinrich
Römling, Ute
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Issue Date
2016-04
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Abstract
Maintenance of protein homeostasis is essential for survival of all organisms. In bacteria, the protein quality control system has a broad physiological impact beyond heat shock resistance, being involved in virulence, antibiotic resistance, as well as protection against environmental stresses. Its contribution to rejuvenation and growth arrest suggests interference with protein quality control to be a novel antimicrobial strategy. Remarkably, a protein quality control module originating from environmental strains has been found to be horizontally transferred to predominant clonal groups of bacteria providing exquisite thermotolerance to recently emerged global pathogens suggesting that novel features related to protein homeostasis contribute to the transition to new environments.
Citation
Protein homeostasis-more than resisting a hot bath. 2016, 30:147-54 Curr. Opin. Microbiol.
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en
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1879-0364