Thumbnail Image
Publication

More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli.

Göhler, Anna-Katharina
; 
Kökpinar, Öznur
; 
Schmidt-Heck, Wolfgang
; ; 
Guthke, Reinhard
; 
Rinas, Ursula
; 
Schuster, Stefan
; 
Jahreis, Knut
; 
Kaleta, Christoph
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2011
Submitted date
Show all metadata
Files
Thumbnail Image
Open Access publication
Adobe PDF, 1.34 MB
Other Titles
Abstract
The pyruvate dehydrogenase regulator protein (PdhR) of Escherichia coli acts as a transcriptional regulator in a pyruvate dependent manner to control central metabolic fluxes. However, the complete PdhR regulon has not yet been uncovered. To achieve an extended understanding of its gene regulatory network, we combined large-scale network inference and experimental verification of results obtained by a systems biology approach.
Citation
More than just a metabolic regulator--elucidation and validation of new targets of PdhR in Escherichia coli. 2011, 5:197 BMC Syst Biol
Affiliation
Department of Genetics, University of Osnabrück, Osnabrück, Germany.
Publisher
Journal
BMC systems biology
URI
http://hdl.handle.net/10033/236989
DOI
10.1186/1752-0509-5-197
PubMed ID
22168595
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1752-0509
EISSN
ISBN
ISMN
Gov't Doc #
Sponsors
License
Archived with thanks to BMC systems biology
Collections
publications of the scientific administration (GFW)
publications of the research group genomeanalytics (GMAK)