Loading...
Synchronous Germinal Center Onset Impacts the Efficiency of Antibody Responses.
Arulraj, Theinmozhi Robert, Philippe A
Arulraj, Theinmozhi
Robert, Philippe A
Citations
Altmetric:
Advisors
Editors
Other Contributors
Issue Date
2019-01-01
Submitted date
Files
Loading...
Open Access publication
Adobe PDF, 758.88 KB
Other Titles
Abstract
The germinal center reaction is an important target for modulating antibody responses. Antibody production from germinal centers is regulated by a negative feedback mechanism termed antibody feedback. By imposing antibody feedback, germinal centers can interact and regulate the output of other germinal centers. Using an agent-based model of the germinal center reaction, we studied the impact of antibody feedback on kinetics and efficiency of a germinal center. Our simulations predict that high feedback of antibodies from germinal centers reduces the production of plasma cells and subsequently the efficiency of the germinal center reaction by promoting earlier termination. Affinity maturation is only weakly improved by increased antibody feedback and ultimately interrupted because of premature termination of the reaction. The model predicts that the asynchronous onset and changes in number of germinal centers could alter the efficiency of antibody response due to changes in feedback by soluble antibodies. Consequently, late initialized germinal centers have a compromised output due to higher antibody feedback from the germinal centers formed earlier. The results demonstrate potential effects of germinal center intercommunication and highlight the importance of understanding germinal center interactions for optimizing the antibody response, in particular, in the elderly and in the context of vaccination.
Citation
Front Immunol. 2019 Sep 6;10:2116. doi: 10.3389/fimmu.2019.02116. eCollection 2019.
Publisher
Journal
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1664-3224