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BIOSYNTHESIS OF CONTACTINHIBIN A PLASMAMEMBRANE GLYCOPROTEIN INVOLVED IN CONTACT-DEPENDENT INHIBITION OF GROWTH
Schütz, Sonja Oesch, Franz Wieser, Raimund J.
Schütz, Sonja
Oesch, Franz
Wieser, Raimund J.
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Issue Date
1991
Submitted date
2024-02-20
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Abstract
Growth of normal diploid human fibroblasts jn vitro is mainly regulated by cell-cell-contacts. We have isolated a 60 - 70 kDa plasma membrane Blycoprotein, named Contactinhibin, which igs involved in the Process of contactinhibition and inhibits the growth of sparsely seeded cells in a concentration dependent, reversible and non toxic manner. Antibodies raised against Contactinhibin released confluently seeded cells from contact-inhibition, while sparsely seeded cells were not affected. The cells treated with anti-Contactinhibin antibodies showed a criss-cross morphology similar to transformed cells. Here we describe the appearance of biosynthetic precursor molecules of Contactinhibin after specific blocking of biosynthesis at an early stage.
Citation
Protein glycosylation, 73 - 76
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Book chapter
conference paper
conference paper
Language
en
Description
Series/Report no.
GBF monographs ; Volume 15
ISSN
0930-4320
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ISBN
1560811846
3527283676
3527283676
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Attribution-NonCommercial-ShareAlike 4.0 International