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Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data.

Martins, José Paulo
; 
Santos, Jorge Miguel
; 
de Almeida, Joana Marto
; 
Filipe, Mariana Alves
; 
de Almeida, Mariana Vargas Teixeira
; 
Almeida, Sílvia Cristina Paiva
; 
Água-Doce, Ana
; 
Varela, Alexandre
; 
Gilljam, Mari
; 
Stellan, Birgitta
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2014
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Abstract
Standardization of mesenchymal stromal cells (MSCs) manufacturing is urgently needed to enable translational activities and ultimately facilitate comparison of clinical trial results. In this work we describe the adaptation of a proprietary method for isolation of a specific umbilical cord tissue-derived population of MSCs, herein designated by its registered trademark as UCX®, towards the production of an advanced therapy medicinal product (ATMP).
Citation
Towards an advanced therapy medicinal product based on mesenchymal stromal cells isolated from the umbilical cord tissue: quality and safety data. 2014, 5 (1):9 Stem Cell Res Ther
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Journal
Stem cell research & therapy
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http://hdl.handle.net/10033/579735
DOI
10.1186/scrt398
PubMed ID
24438697
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Article
Language
en
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1757-6512
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Publications of Dept. Gene Regulation and Differentiation (RDIF)