Loading...
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells.
Simma, Narasimhulu Bose, Tanima Kahlfuss, Sascha Mankiewicz, Judith Lowinus, Theresa Lühder, Fred Schüler, Thomas Schraven, Burkhart Heine, Martin Bommhardt, Ursula
Simma, Narasimhulu
Bose, Tanima
Kahlfuss, Sascha
Mankiewicz, Judith
Lowinus, Theresa
Lühder, Fred
Schüler, Thomas
Schraven, Burkhart
Heine, Martin
Bommhardt, Ursula
Files
Loading...
Open Access publication
Adobe PDF, 5.11 MB
Other Titles
Abstract
B cells are important effectors and regulators of adaptive and innate immune responses, inflammation and autoimmunity, for instance in anti-NMDA-receptor (NMDAR) encephalitis. Thus, pharmacological modulation of B-cell function could be an effective regimen in therapeutic strategies. Since the non-competitive NMDAR antagonist memantine is clinically applied to treat advanced Alzheimer`s disease and ketamine is supposed to improve the course of resistant depression, it is important to know how these drugs affect B-cell function.
Citation
NMDA-receptor antagonists block B-cell function but foster IL-10 production in BCR/CD40-activated B cells. 2014, 12:75 Cell Commun. Signal
Publisher
PubMed ID
PubMed Central ID
Additional Links
Embedded video
Type
Article
Language
en
Description
Series/Report no.
ISSN
1478-811X