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Contiguous Quaternary Carbons: A Selection of Total Syntheses.

Eggert, Alina
; 
Etling, Christoph
; 
Lübken, Dennis
; 
Saxarra, Marius
; 
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Issue Date
2020-08-24
Submitted date
2020-07-22
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Abstract
Contiguous quaternary carbons in terpene natural products remain a major challenge in total synthesis. Synthetic strategies to overcome this challenge will be a pivotal prerequisite to the medicinal application of natural products and their analogs or derivatives. In this review, we cover syntheses of natural products that exhibit a dense assembly of quaternary carbons and whose syntheses were uncompleted until recently. While discussing their syntheses, we not only cover the most recent total syntheses but also provide an update on the status quo of modern syntheses of complex natural products. Herein, we review (±)-canataxpropellane, (+)-waihoensene, (-)-illisimonin A and (±)-11-O-debenzoyltashironin as prominent examples of natural products bearing contiguous quaternary carbons.
Citation
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Publisher
Journal
Molecules (Basel, Switzerland)
URI
http://hdl.handle.net/10033/623229
DOI
10.3390/molecules25173841
PubMed ID
32847075
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Article
Language
en
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ISSN
EISSN
1420-3049
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Attribution 4.0 International
cb
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publications of the department medicinal chemistry (MCH)