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Genome-guided design of a defined mouse microbiota that confers colonization resistance against Salmonella enterica serovar Typhimurium.
Brugiroux, Sandrine Beutler, Markus Pfann, Carina Garzetti, Debora Ruscheweyh, Hans-Joachim Ring, Diana Diehl, Manuel Herp, Simone Lötscher, Yvonne Hussain, Saib
Brugiroux, Sandrine
Beutler, Markus
Pfann, Carina
Garzetti, Debora
Ruscheweyh, Hans-Joachim
Ring, Diana
Diehl, Manuel
Herp, Simone
Lötscher, Yvonne
Hussain, Saib
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2016-11-21
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Protection against enteric infections, also termed colonization resistance, results from mutualistic interactions of the host and its indigenous microbes. The gut microbiota of humans and mice is highly diverse and it is therefore challenging to assign specific properties to its individual members. Here, we have used a collection of murine bacterial strains and a modular design approach to create a minimal bacterial community that, once established in germ-free mice, provided colonization resistance against the human enteric pathogen Salmonella enterica serovar Typhimurium (S. Tm). Initially, a community of 12 strains, termed Oligo-Mouse-Microbiota (Oligo-MM
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2058-5276
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Attribution-NonCommercial-ShareAlike 3.0 United States