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In vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways.

Goikoetxea, Estibalitz
; 
Murgia, Xabier
; 
Serna-Grande, Pablo
; 
Valls-i-Soler, Adolf
; 
Rey-Santano, Carmen
; 
Rivas, Alejandro
; 
Antón, Raúl
; 
Basterretxea, Francisco J
; 
Miñambres, Lorena
; 
Méndez, Estíbaliz
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2014
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Abstract
Aerosol delivery holds potential to release surfactant or perfluorocarbon (PFC) to the lungs of neonates with respiratory distress syndrome with minimal airway manipulation. Nevertheless, lung deposition in neonates tends to be very low due to extremely low lung volumes, narrow airways and high respiratory rates. In the present study, the feasibility of enhancing lung deposition by intracorporeal delivery of aerosols was investigated using a physical model of neonatal conducting airways.
Citation
In vitro surfactant and perfluorocarbon aerosol deposition in a neonatal physical model of the upper conducting airways. 2014, 9 (9):e106835 PLoS ONE
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PloS one
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http://hdl.handle.net/10033/338661
DOI
10.1371/journal.pone.0106835
PubMed ID
25211475
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Article
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en
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1932-6203
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publications of the research group drug delivery ([HIPS] DDEL)