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Myxobacteria: natural pharmaceutical factories.

Diez, Juana
; 
Martinez, Javier P
; 
Mestres, Jordi
; 
Sasse, Florenz
; 
Frank, Ronald
; 
Meyerhans, Andreas
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2012
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Abstract
Myxobacteria are amongst the top producers of natural products. The diversity and unique structural properties of their secondary metabolites is what make these social microbes highly attractive for drug discovery. Screening of products derived from these bacteria has revealed a puzzling amount of hits against infectious and non-infectious human diseases. Preying mainly on other bacteria and fungi, why would these ancient hunters manufacture compounds beneficial for us? The answer may be the targeting of shared processes and structural features conserved throughout evolution.
Citation
Myxobacteria: natural pharmaceutical factories. 2012, 11:52 Microb. Cell Fact.
Affiliation
Helmholtz Centre for infection research, Inhoffenstr. 7, D-38124 Braunschweig, Germany.
Publisher
Journal
Microbial cell factories
URI
http://hdl.handle.net/10033/595433
DOI
10.1186/1475-2859-11-52
PubMed ID
22545867
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Article
Language
en
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ISSN
1475-2859
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openAccess
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Publications of the research group Chemical Biology (CBIO)