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Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae.
Rebets, Yuriy Tokovenko, Bogdan Lushchyk, Igor Rückert, Christian Zaburannyi, Nestor Bechthold, Andreas Kalinowski, Jörn
Rebets, Yuriy
Tokovenko, Bogdan
Lushchyk, Igor
Rückert, Christian
Zaburannyi, Nestor
Bechthold, Andreas
Kalinowski, Jörn
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Abstract
Kutzneria is a representative of a rarely observed genus of the family Pseudonocardiaceae. Kutzneria species were initially placed in the Streptosporangiaceae genus and later reconsidered to be an independent genus of the Pseudonocardiaceae. Kutzneria albida is one of the eight known members of the genus. This strain is a unique producer of the glycosylated polyole macrolide aculeximycin which is active against both bacteria and fungi. Kutzneria albida genome sequencing and analysis allow a deeper understanding of evolution of this genus of Pseudonocardiaceae, provide new insight in the phylogeny of the genus, as well as decipher the hidden secondary metabolic potential of these rare actinobacteria.
Citation
Complete genome sequence of producer of the glycopeptide antibiotic Aculeximycin Kutzneria albida DSM 43870T, a representative of minor genus of Pseudonocardiaceae. 2014, 15:885 BMC Genomics
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en
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1471-2164