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The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation.
Sirma, Hüseyin Kumar, Mukesh Meena, Jitendra K Witt, Britta Weise, Julia M Lechel, Andre Ande, Satyanarayana Sakk, Vadim Guguen-Guillouzo, Christiane Zender, Lars
Sirma, Hüseyin
Kumar, Mukesh
Meena, Jitendra K
Witt, Britta
Weise, Julia M
Lechel, Andre
Ande, Satyanarayana
Sakk, Vadim
Guguen-Guillouzo, Christiane
Zender, Lars
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2011-07
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Abstract
Telomerase activity has not been detected in healthy human liver biopsy samples, but it is up-regulated in most human liver tumors. It is not clear whether telomerase is activated in response to acute or chronic liver injury. Telomerase activity is closely associated with expression of its catalytic subunit, telomerase reverse transcriptase (TERT). We analyzed the activity of the human TERT (hTERT) promoter during liver regeneration in vivo and hepatocyte proliferation in vitro.
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The promoter of human telomerase reverse transcriptase is activated during liver regeneration and hepatocyte proliferation. 2011, 141 (1):326-37, 337.e1-3 Gastroenterology
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en
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1528-0012